Clinically relevant thalassemia falls into two major categories: transfusion-dependent thalassemia and non-transfusion-dependent thalassemia (NTDT). Patients with either form of the disease can develop serious iron overload.

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Myelodysplastic Syndromes

Although relatively rare, myelodysplastic syndromes (MDS) are the most common malignant bone marrow disorders.

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Sickle Cell Disease

Iron burden is a major determinant of morbidity and mortality in patients with sickle cell disease.

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Other Anemias

Aplastic anemia (AA) is a heterogeneous group of rare diseases characterized by pancytopenia, hypocellular bone marrow, and bone marrow failure.

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