Iron overload and subsequent accumulation are a significant problem that is potentially toxic and debilitating. Iron burden is a determinant of morbidity and mortality in sickle cell disease (SCD).1-3
A positive correlation has been shown between severity of iron overload and frequency of hospitalization in patients with SCD.2
Iron overload contributes to increased morbidity and mortality in patients with SCD (Figure). Even though SCD patients receive intermittent transfusions, as opposed to thalassemia patients who receive regular transfusions, they can still experience the fatal consequences of iron overload.3,4,5
Figure. Iron overload is associated with poor outcome in SCD.3
TS = transferrin saturation.
All fields are required.
You are now leaving the IronHealthalliance.com website by opening an external website independently operated and not managed by Novartis. Novartis assumes no responsibility for the site you are about to visit. If you do not wish to leave this site, click "Cancel." Otherwise, click "Continue".