For healthcare professionals outside the U.S.
Print Text Size

Consequences of Iron Overload in SCD

Iron overload is a major determinant of morbidity and mortality in Sickle Cell Disease (SCD).1 Patients with SCD receive regular blood transfusions to lower their risk of stroke, but just 10 transfusions (20 transfused units of blood) can increase the risk of iron overload and its consequences, regardless of how much time has passed between transfusions.2 In one study, elevated serum ferritin in SCD patients correlated with an increase in painful episodes and, in another study, patients with iron overload had 12 times the rate of mortality.1-4

For more information on the effects of iron overload in SCD, click here.


  1. Ballas SK. Semin Hematol. 2001;38(1 Suppl 1):30-36.
  2. Gabutti V, Piga A. Acta Haematol. 1996;95:26-36.
  3. National Heart, Lung, and Blood Institute. The Management of Sickle Cell Disease.
  4. 4th ed. Bethesda, MD: National Institutes of Health; 2002. NIH publication 02-2117.

Send to a Colleague

Your privacy is important. We will not retain any of the information you enter on this page. Learn more about our privacy policy.

All fields are required.

Your name:
Your colleague's name:
Your colleague's e-mail address:


You are now leaving the website by opening an external website independently operated and not managed by Novartis. Novartis assumes no responsibility for the site you are about to visit. If you do not wish to leave this site, click "Cancel." Otherwise, click "Continue".