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Consequences of Iron Overload in SCD

Iron overload is a major determinant of morbidity and mortality in Sickle Cell Disease (SCD).1 Patients with SCD receive regular blood transfusions to lower their risk of stroke, but just 10 transfusions (20 transfused units of blood) can increase the risk of iron overload and its consequences, regardless of how much time has passed between transfusions.2 In one study, elevated serum ferritin in SCD patients correlated with an increase in painful episodes and, in another study, patients with iron overload had 12 times the rate of mortality.1

For more information on the effects of iron overload in SCD, click here.

References

  1. Ballas SK. Iron overload is a determinant of morbidity and mortality in adult patients with sickle cell disease. Semin Hematol. 2001;38(1 Suppl 1):30-36.
  2. Gabutti V, Piga A. Results of long-term iron-chelating therapy. Acta Haematol. 1996;95(1):26-36.

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